California Bureau of Investigation consultant Thomas Jane along with Senior Agent Teresa Lisbon and her team, investigate a double murder in which a pro golfer's wife and her doctor were killed in Palm Springs.

Lisbon and the team investigate the death of a waitress in Napa Valley as Patrick decides to take matters into his own hands by going undercover.

When the body of a high school girl is found on the beach, Patrick decides to employ a mentalist trap in order to get her friends to reveal the truth behind her death.

After a big investor is found dead locked up in his secret safe room, the unit makes all the effort and they quickly find out that he had a second life and his business was a long time gone into fraud. Once again there is a lot at stake and with the political repercussion of the case, everyone, 's job is at risk and only a mentalist trap can make the true killer revel it self.

When a girl is found covered in blood and holding the weapon that killed her best friend, she is named as the lead suspect to the murder. However, she cannot remember what happened. But Jane believes in her innocence and tries a risky move in order to help her regain her memory.

Patrick Jane don't believe the police have the correct person on trial for the murders and drug deal of the states witness.

Patrick sets up a seance to prove a so-called psychic is not only a fraud, but a murderer too.

When the police name a drug dealer as their number one suspect in the murders of the State's witness, Patrick Jane sees a different motive and suspect.

When three National Guardsmen are found murdered, Patrick Jane and the team go undercover to investigate.

The poisoning of a leading scientific researcher is of a personal interest for Patrick Jane when he learns the victim's wife is the prime suspect, and was Jane's former psychiatrist.

Patrick Jane becomes focused on a convicted murderer who promises to reveal information on Red John upon his release, and quits the CBI in order to prove the prisoner's innocence.

When Cody Elkins, a high school football star, is found murdered, all trails point to the local witch, as her motive could be revenge for Cody stealing, torturing and killing her cat. When the CBI goes to investigate, she admits to having put a killing spell on Cody, but Jane still shows skepticism.

A business tycoon's son was found dead near where a $50 million painting once hung in his father's office. Jane and the CBI try to find out how he might have been involved and who else is responsible.

With Patrick Jane's help, Cho goes undercover as a ladies' man with all the right moves in order to catch a killer who has his own set of pseudo-mentalist techniques.

As Jane and the team investigate the poisoning death of the queen bee in a country club, they discover that the community is full of secrets, including love affairs and drug abuse.

Patrick Jane must rely on his other senses during the murder investigation of a financial advisor when he loses his sight as a result of an explosion.

A story of greed and betrayal pits Patrick Jane against a group of financiers when the CBI investigates a series of murders at a corporate retreat in the wilds of the Sierra Nevada foothills.

Patrick Jane and the CBI team track down a mastermind who hypnotizes people into doing their bidding.

Some longtime fans were alienated by the show in season six, due to the different tone taken by most stand-alone episodes after the move to Los Angeles, California[44] Rather than adhering to the previous style of "monsters of the week", they were often romantic or gently humorous or both, such as "Arcadia" and "Terms of Endearment".

When the body of an ex-mobster who was in witness protection turns up in a riverbed with a bullet in the forehead, Jane and the team trace the body back to find a list of suspects -- The wife, the boss, the two Federal marshals on supervisory detail, the local biker gang member, and the mobster whose two sons went to jail by his testimony, who just happens to have retired nearby. Meanwhile, it's Lisbon's birthday. Did Jane forget?

Patrick Jane uses his mentalist skills to play suspects off each other in order to solve the case of a wealthy software company CEO found murdered on his yacht.

Patrick Jane must find a clever way to convince the troubled kids at a wilderness program to confide in him about what really happened surrounding the death of one of their peers.

Lisbon suspects that serial killer Red John is drawing Patrick Jane into a trap when the CBI team investigates the murder of a young girl and the abduction of her twin sister.